Little MacvsIron Mike Tyson (Legends)

Little Mac Little Mac beats Mike canonically. Though in the Punch Out verse, both are insane because of the power of some of those boxers they're going up against. (Don Flamenco can launch a cow into the air several miles? Great Tiger can straight up teleport? There are some superhumans in this verse for sure.)

Little Mac Mike is just a normal human. Mac is clearly some type of super human b/c of his stats. Mike may be greater than most humans but he's not super human.

Iron Mike Tyson (Legends) Ironically, though Mac could beat Mike on Punchout with a skilled player, most players probably did not do it even once. The game was that tough. There have also been more lost games(as Mac) to Mike than won over the years. There are even some experts that spent 100s of times trying before they got him even once. I could eventually beat him and still can, but I would not be surprised if I had lost more times than I won. In fact, I'm almost certain of it. And, if you brought Mac into the real world, there's no way he can win. So much for Little Mac against Tyson...